The two articles summarized below containing data derived by meta-analysis of all available published studies, with added analysis of unpublished studies, using EDTA chelation therapy. They show a very consistent and high level of benefit in more than 85% of patients



The Correlation Between EDTA Chelation Therapy and Improvement in Cardiovascular Function: A Meta-Analysis

L. Terry Chappell, MD

John P. Stahl, PhD

ABSTRACT: In order to establish whether there is value in treating cardiovascular disease with intravenous EDTA chelation therapy, a meta-analysis was done, based on currently available scientific literature. A thorough literature search identified 40 articles on the subject. Nineteen studies met the criteria for inclusion with data on 22,765 patients. The meta-analysis revealed a statistical correlation coefficient of 0.88, which indicates a high positive relationship between EDTA therapy and improved cardiovascular function. Eighty-seven per cent of the patients included in the meta-analysis demonstrated clinical improvement by objective before-and-after testing.



EDTA Chelation Treatment for Vascular Disease: A Meta-Analysis Using Unpublished Data

L. Terry Chappell, MD

John P. Stahl, PhD

Ronald Evans, MA

ABSTRACT: The authors previously reported the results of a meta-analysis on the correlation between EDTA therapy and improvement in cardiovascular function where only published data were used in the analysis.  Many analysts suggest that using exclusively published data in a meta-analysis leads to a lowered confidence level in the results because of the possibility of publication bias. In order to improve the confidence level if possible in the results of their original paper the authors repeated the study using unpublished data. Unpublished “file drawer” data were collected from 32 clinicians who utilize intravenous EDTA with essentially the same protocol as was used in the original study.  Various objective measurements demonstrated improvement in 1086 or 88% of the 1241 patients reported with an overall statistical correlation coefficient of 0.88.  A comparison of the studies using unpublished data with published data shows that the results are essentially the same.  These data provide additional confidence of the effectiveness of EDTA treatment.

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